UNIVERSIDAD DE GUAYAQUIL
DEPARTMENT OF CHEMICAL SCIENCES
Ciudadela Universitaria ¨Dr. Salvador Allende¨
Telephone: 2293680, E-mail: fcquimic@ug.edu.ec
Guayaquil, Ecuador
FINAL REPORT - SUMMARY
CODE: 38/05
TITLE:
Establishment of the potential anti-inflammatory effect of the product known as Quina, originating from NutraMedix Laboratories, LLC, Florida
OBJECTIVE:
To study the possible anti-inflammatory effect of QUINA, measured by edemas, induced by carragenin in the feet of laboratory mice.
Description OF THE DOSAGE, METHOD of administration and duration of the test:
The test was achieved by following the method established by CYTED and using the dosage indicated for each mouse.
The Quina was administered orally.
The Quina and the widely used pharmaceutical anti-inflammatory indomethycine were applied orally one hour before the application of the carragenin.
AnalITICAL results:
The results of the average value of the weights of the treated feet, and the standard deviations, are found in Table #1:
|
Group |
Weigh of feet (g) (Mean ± st. dev.) |
% of inflammation |
% of inhibition
|
|
Carragenina 1% |
0.3 ±0.6a |
96.1
|
--- |
|
Carragenina +Quina
|
0.18±1.0b |
38% |
40% |
|
Carragenina + Indomethycine 10mg/kg
|
0.20±1.0c |
53% |
35% |
Statistical significance between (a) with respect to (b) and (c) (p<.05)
As is demonstrated in Table # 1, Quina showed a statistically significant anti-inflammatory effect with respect to the control group with carragenin and superior to the referenced widely used non-steroidal pharmaceutical indomethycine. These results indicate the potential for this product as an anti-inflammatory.
This result marks guidelines for the investigation of the mechanism of action of this product as a potent anti-inflammatory for popular use.
CONCLUSIONS:
Was demonstrated that QUINA has an anti-inflammatory effect.
General conclusions:
Quina was demonstrated to have anti-inflammatory effect similar to indomethycine and can be used to address inflammation from inflammatory agents such as carragenine, as observed in animal testing and as appears in specialized literature.
PERSONNEL RESPONSIBLE FOR THE STUDY:
Responsible Professional: Signature:
Dr. Diadelis Remirez Figueredo
Date: 07/26/05