UNIVERSIDAD DE GUAYAQUIL
DEPARTMENT OF CHEMICAL SCIENCES
Ciudadela Universitaria ¨Dr. Salvador Allende¨
Telephone: 2293680, E-mail: fcquimic@ug.edu.ec
Guayaquil, Ecuador
FINAL REPORT - SUMMARY
CODE: 38/05
TITLE:
Establishment of the potential anti-inflammatory effect (via orally) of the product known as Cumanda, originating from NutraMedix Laboratories, LLC, Florida
OBJECTIVE:
To study the possible anti-inflammatory effect of CUMANDA, measured by edemas, induced by carragenin in the feet of laboratory mice.
Description OF THE DOSAGE, METHOD of administration and duration of the test:
The test was achieved by following the method established by CYTED and using the dosage indicated for each mouse.
The Cumanda and the control medications celecoxib and ibuprofen were administered orally one hour before the application of the carragenine.
AnalITICAL results:
The results of the average value of the weights of the treated feet, the standard deviations, the percentage of inflammation and the percentage of inhibition are found in Table #1.
Table # 1: Anti-inflammatory effect of Cumanda on the edema induced by Carragenine.
|
Group |
Weigh of feet (g) (Mean ± st. dev.) |
% of inflammation |
% of inhibition
|
|
Carragenine 1% |
0.3 ±0.6a |
96.1
|
--- |
|
Carragenine +Ibuprofen
|
0.2 ±0.3b |
42% |
100% |
|
Carragenine + Cumanda
|
0.21±1.0b |
61% |
88.2% |
|
Carragenine + Celecoxib
|
0.22±0.6b |
54% |
78.5% |
As is demonstrated in Table # 1, Cumanda showed an anti-inflammatory effect similar to the conventional anti-inflammatories ibuprofen and celecoxib. The pharmaceutical celecoxib (inhibitor of ciclooxigenasis 2) showed a lesser anti-inflammatory effect than ibuprofen, a non-steroidal anti-inflammatory. It is important to note that Cumanda was capable of demonstrating this effect in the face of a potent inflammatory agent such as carragenine, which after 5 hours releases a series of mediators which are involved in the inflammatory response.
CONCLUSIONS:
1. Cumanda demonstrated to have an anti-inflammatory effect similar to widely used conventional anti-inflamatories.
2. Ibuprofen and Celecoxib were also demonstrated to possess the effect for which they are sold.
General conclusions:
Cumanda demonstrated to have anti-inflammatory effect similar to Ibuprofen and Celecoxib and can be used to reduce inflammation from inflammatory agents such as carragenine, as observed in animal testing and as appears in specialized literature.
Date: 07/18/05