UNIVERSIDAD DE
DEPARTMENT OF CHEMICAL SCIENCES
Ciudadela Universitaria ¨Dr. Salvador Allende¨
Telephone: 2293680, E-mail: fcquimic@ug.edu.ec
Guayaquil, Ecuador
FINAL
REPORT - SUMMARY
CODE: 38/05
TITLE:
Establishment
of the potential analgesic effect of the product known as Cumanda, originating
from NutraMedix Laboratories, LLC,
OBJECTIVES:
To
study the possible analgesic effect of Cumanda,
measured by stretching and writhing in laboratory mice.
Description OF THE DOSAGE, METHOD of
administration
The
test was achieved by following the method established by CYTED and using the
dose of 0.5 mL/20g each mouse. Oral administration was used for the testing and
the reference materials, using an intragastric canula. The analgesic was administered
intravenously.
AnalITICAL
results:
The
results of the number of writhing and stretches are found in Table #1.
|
UNIVERSIDAD DE DEPARTMENT OF CHEMICAL SCIENCES |
|||
|
TABLE # 1. STUDY OF THE
POSSIBLE ANALGESIC EFFECT OF CUMANDA |
|||
|
Group
|
Animal |
Writhing |
Stretching |
|
Analgesic
Agent
|
1 |
13 |
1 |
|
|
2 |
3 |
2 |
|
|
3 |
7 |
10 |
|
|
4 |
13 |
3 |
|
|
5 |
8 |
2 |
|
Total |
44 |
18 |
|
|
Mean
± s.d. |
8.8
± 4.2 |
3.6
± 3.6 |
|
|
SAA +
Analgesic Agent
|
1 |
0 |
0 |
|
|
2 |
1 |
0 |
|
|
3 |
3 |
0 |
|
|
4 |
0 |
0 |
|
|
5 |
0 |
0 |
|
Total |
4 |
0 |
|
|
Mean
± s.d. |
0.8
± 1.3 |
0
± 0 |
|
|
Cumanda +
Analgesic Agent
|
1 |
1 |
0 |
|
|
2 |
7 |
0 |
|
|
3 |
3 |
0 |
|
|
4 |
3 |
0 |
|
|
5 |
0 |
0 |
|
Total |
14 |
0 |
|
|
Mean
± s.d. |
2.8
± 2.6 |
0
± 0 |
|
As
can be seen in the table, the number of writhing and stretches counted in the
proprietary drug group, as well as in the substance under study, were less than
that of the analgesic group. When
the percentage of analgesia is calculated, our product produces 86%, which
indicates its analgesic effect.
CONCLUSIONS:
1-
Cumanda was demonstrated to have an
analgesic effect as assumed in the
objectives of the trial.
2-
Aspirin showed the greatest results.
General conclusions:
Cumanda
was
demonstrated to have an analgesic effect in the study using mice, as appears in
specialized literature.
Date:
05/03/05